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Longevity Research

SEMAX

4.9ReviewsRead more

Semax is a next-generation peptide designed to support sharper focus, clearer thinking, stronger memory, and greater mental resilience. Often described as a “brain-performance” peptide, it works with key pathways involved in learning, concentration, and cognitive recovery—helping you feel more switched on, mentally agile, and ready to perform.

Batch details included Manufactured in Canada
$54 CADCAD · shipping and taxes shown at checkout
1

SEMAX is supplied as 5 mg of lyophilized powder in a sealed glass vial for laboratory research. Confirm the selected vial and batch details before use.

Selected strength5 mg
FormatLyophilized powder
PackageSealed glass vial
Catalogue codePP-SEMAX-5-MG
Research guide

Understanding Semax

Explore the science, research focus, and key information behind this compound.

What is Semax?

Semax is an ACTH-derived research peptide studied in neurotrophic, cognitive, and neuronal-response models. SEMAX is commonly selected when a study centres on ACTH-derived peptide structure and neurotrophic signalling.

What Researchers Study

Researchers may use defined neurotrophin, gene-expression, oxidative-stress, or neuronal-survival endpoints instead of a general cognition label. They may also distinguish the Semax sequence from ACTH and from shorter ACTH fragments when choosing controls. They may also keep preclinical neuroprotection results separate from human functional outcomes and route-specific clinical reports.

How Semax Works

Rather than one settled receptor target, research reports changes in neurotrophin expression, melanocortin-related signalling, oxidative stress, and peptide-regulatory systems. In plain language, Semax is a multi-signal neuroresearch peptide, and the exact pathway remains model-dependent. Semax has regional medical-use history, particularly in Russia, but is not FDA- or Health Canada-approved. Much of the human literature is small, regional, or not independently replicated to modern registration-trial standards.

Research at a Glance

Neurotrophin and neuronal-response signals have been reported. Cell and animal studies have described changes in BDNF-related expression, oxidative stress, and injury responses. These findings support further mechanism work, not a guaranteed cognitive or recovery effect. The clinical literature needs cautious reading. Regional studies are part of the evidence base, but differences in trial reporting, route, comparators, and independent replication limit how confidently broad claims can be made. A defined analogue—not “ACTH without side effects”. Semax was derived from an ACTH fragment, but its biology should be described from direct Semax evidence rather than assumed from the parent hormone.

Read the full Semax evidence guideStudy design, primary sources, limitations, and unanswered questions.Open guide
Research-use statement

This product is offered for laboratory research only. It is not for human consumption and is not represented as a medicine, treatment, supplement or substitute for an approved product.

Preparation guide

Calculate. Prepare. Store.

Plan the concentration and measurement volume before adding water, then follow the preparation and storage steps.

Step 1: Calculate

Confirm the vial strength and planned water volume before adding water.

SEMAX · 5 mg selected

Calculated result
Measurement volumeEnter a target amount
Concentration2.5 mg/mL

For laboratory calculation only. Confirm the vial label and research protocol before preparation.

Step 2: Prepare

Most lyophilized vials are prepared with 2 mL of bacteriostatic water, unless otherwise stated on the product page or vial label.

After confirming the calculation, slowly add the planned water volume down the inside wall of the vial.

Do not shake the vialLyophilized peptides can be sensitive to vigorous agitation. Gently swirl until fully dissolved.

Step 3: Store

Prepared vialsRefrigerate at 2–8°C

Unprepared vialsKeep cool and dry, away from heat, moisture, and direct sunlight

Shipping & delivery

Picked and shipped within 24 hours.

More than 10,000 products have been shipped and delivered across Canada. In-stock orders are checked and packed within 24 hours, then shipped with Canada Post. Tracking is sent after the parcel's first carrier scan.

Bilingual Shipped by Canada Post logo with English to the left and French to the rightTrack your package

Customer reviews

4.9★★★★★

10 sample reviews

Share your experience

Reviews are checked before publication. Your email is never displayed.

10 reviewsShowing 5
Alex R. Verified sample
British Columbia
★★★★★
BPC-157 - 10 mg

Exactly what I expected

BPC-157 arrived clean and well protected. The 10 mg label was easy to read, and I found the batch details without having to hunt for them.

Sample review
Morgan R. Verified sample
Ontario
★★★★★
Tirzepatide - 10 mg

Arrived well packed

Quick update on the Tirzepatide: ordering was simple, tracking appeared after the first scan, and everything in the mailer looked tidy.

Sample review
Jamie R. Verified sample
Alberta
★★★★★
Semaglutide - 5 mg

Quick and straightforward

This was my first time ordering Semaglutide. The strength options were clear and the storage notes were right where I expected them to be.

Sample review
Taylor R. Verified sample
Quebec
★★★★★
Retatrutide - 30 mg

Clear from the start

Short and sweet—Retatrutide was well packed, clearly labelled and exactly as listed.

Sample review
Jordan R. Verified sample
Nova Scotia
★★★★★
TB-500 - 10 mg

No surprises

I took a minute to compare the TB-500 options before choosing 10 mg. The page made that easy, and the parcel arrived in good condition.

Sample review
Frequently asked questions

Everything worth knowing before you order.

Product, documentation, shipping and support answers—without making you hunt through the site.

Are your peptides made in Canada?

Yes. Puffin Peptides sources its research peptides from Canada’s largest premium peptide manufacturer, then labels, packages, and ships them from Canada. Product and batch information remains tied to each vial.

Are your products intended for human consumption?

No. All Puffin Peptides products are supplied strictly for laboratory research and analytical use. They are not for human or veterinary consumption and are not represented as medicines, treatments, supplements, or substitutes for approved products.

Do you provide batch-specific documentation?

Yes. Batch-specific documentation is published for the applicable product strength and lot when available. Open Batch details on the product page; if a document has not yet been published, contact support with the product name, strength, and lot number.

What is a lyophilized peptide?

A lyophilized peptide is a peptide that has been freeze-dried into a powder by removing water under controlled low-temperature and vacuum conditions. This format supports stability during storage and allows the material to be prepared according to the product label and research protocol.

How should peptides be stored?

Always follow the storage instructions for the exact product and lot. Unless otherwise stated, keep unprepared lyophilized vials cool and dry, away from heat, moisture, and direct sunlight. Refrigerate prepared vials at 2–8°C and avoid repeated freeze-thaw cycles.

Do all peptides use the same preparation method?

No. The correct diluent, volume, and preparation method can vary by product. Most Puffin lyophilized vials use 2 mL of bacteriostatic water unless the product page or vial label says otherwise. Add liquid slowly down the inside wall, gently swirl, and never shake the vial.

How do I use the peptide calculator?

Select the vial strength, enter the planned water volume, and add a target amount if you want a measurement-volume result. The calculator displays the resulting concentration and measurement for laboratory planning only. Confirm the vial label and research protocol before preparation.

What payment methods do you accept?

Puffin Peptides accepts Visa, Mastercard, Interac, and Visa Debit. Available payment methods are shown at checkout before payment is submitted. Puffin Peptides does not collect payment details by email or through customer-support messages.

Is payment processed securely?

Payment is handled through the secure payment provider displayed at checkout. Puffin Peptides does not store complete payment-card details and will never ask you to send them by email or through a support message.

Are prices listed in CAD?

Yes. Product prices, order subtotals, discounts, and free-shipping thresholds are shown in Canadian dollars. Applicable taxes and any delivery charges appear in the order summary before completion.

How are orders shipped?

In-stock orders are checked, protected, and packed within 24 hours, then shipped across Canada with Canada Post. Product-specific handling requirements are followed during fulfilment.

Do you offer tracking?

Yes. Canada Post tracking is provided after the parcel receives its first carrier scan. Use the tracking link in the shipping section or the link provided with your order to follow the parcel to delivery.

How long does shipping take?

In-stock orders are picked, packed, and shipped within 24 hours. Delivery time varies by destination, Canada Post service, weather, and other carrier conditions; the tracking page provides the most current delivery estimate after the first scan.

Do you offer free shipping?

Yes. Standard tracked Canada Post delivery is complimentary when the discounted order subtotal reaches $250 CAD before tax. Any remote-area surcharge or service exclusion is shown before order completion.

What is your return or replacement policy?

Because research products require controlled handling, return eligibility depends on the item and whether it can safely re-enter inventory. Contact support within 48 hours for an incorrect, incomplete, or damaged order. Confirmed issues are reviewed for replacement, store credit, or refund.

What should I do if my order arrives damaged?

Contact support within 48 hours of delivery with your order number and clear photos of the shipping parcel, packaging, and affected vial. Keep all packaging until the review is complete. Verified transit damage is assessed for replacement, store credit, or refund.

Can I change or cancel my order?

Contact support as soon as possible. An order can be changed or cancelled only before packing and fulfilment begin, so requests cannot be guaranteed once the order is being prepared or has shipped.

What makes Puffin Peptides different?

Puffin combines premium Canadian sourcing with clear vial strengths, batch-specific documentation, transparent CAD pricing, preparation and storage guidance, and responsive Canadian support. More than 10,000 products have been shipped and delivered across Canada.

How can I contact Puffin Peptides?

Email support@puffinpeptides.ca at any time. The support team responds Monday through Friday, 9:00–17:00 Pacific Time. Include the product name, catalogue code, lot number, or order number when available so the team can help quickly.