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Every Peptide Explained & Sourced
Longevity Research

MOTS-C

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Power your body at the cellular level. MOTS-c is a mitochondria-derived peptide studied for its potential to support energy production, metabolic efficiency, endurance, and glucose use. Often explored for performance and healthy aging, it is designed to help the body adapt to physical stress and make better use of its natural fuel.

Batch details included Manufactured in Canada
$77 CADCAD · shipping and taxes shown at checkout

MOTS-C is supplied as 10 mg of lyophilized powder in a sealed glass vial for laboratory research. Confirm the selected vial and batch details before preparation.

Selected strength10 mg
Purity99.12%
TestingHPLC-UV
BatchPP-LOT-023
+ Show Scientific Details− Hide Scientific Details
CAS number1627580-64-6
Compound classMitochondrial-derived peptide
Peptide length16 amino acids
SequenceMRWQEMGYIFYPRKLR
Molecular formulaC101H152N28O22S2
Molecular weight2174.6 g/mol
Research themesMitochondrial signalling · Metabolic stress · Skeletal muscle
Scientific profile

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial 12S rRNA and studied in cellular metabolic adaptation and exercise-responsive signalling.

Product guide

MOTS-C Explained

A clear, quick look at what MOTS-C is, how it works, and why it is being studied.

What is MOTS-C supposed to help with?

MOTS-C is best known for cellular energy, metabolism, endurance, and healthy aging. It interests people who want their cells to make better use of the fuel already available.

Research Context

MOTS-c is a mitochondrial-derived peptide encoded within mitochondrial 12S rRNA and studied in metabolic stress, insulin sensitivity, skeletal-muscle signalling and exercise biology. Intervention evidence remains weighted toward preclinical models. [1]

What are mitochondria, and why should I care?

Mitochondria are the tiny power plants inside your cells. When they handle fuel well, the body has more usable energy for movement, recovery, and everyday demands.

Research Context

Mitochondria generate much of the ATP used by cells and also participate in redox signalling and metabolic adaptation. MOTS-c is unusual because it links mitochondrial genetics with signalling that can alter nuclear gene expression and whole-cell metabolism. [1]

What could better cellular energy feel like?

Think less about a sudden buzz and more about having a deeper battery. The goal is steadier fuel use and greater resilience when work, training, or a long day asks more from you.

Research Context

Bioenergetics cannot be translated into a guaranteed subjective feeling of “more energy.” Research measures metabolic signalling, glucose handling and exercise-related endpoints; subjective energy requires separate human evidence. [1]

Does MOTS-C feel like caffeine?

No. Caffeine turns up alertness for a while; MOTS-C is studied for how cells manage fuel and stress. It is more like improving the power system than pressing a temporary boost button.

Research Context

MOTS-c is not a classical stimulant. Its research focuses on mitochondrial and metabolic signalling rather than an acute stimulant mechanism. [1]

Why do active people look into MOTS-C?

Exercise demands that muscles produce energy quickly and efficiently. MOTS-C attracts interest because its biology connects endurance, fuel use, and the way cells adapt when energy demand rises.

Research Context

MOTS-c is exercise-responsive, and experimental work links it to skeletal-muscle adaptation and physical capacity. Human exercise findings are interesting but do not establish it as a proven performance-enhancing intervention. [1]

Can MOTS-C help with weight management?

That interest comes from metabolism rather than appetite suppression. If cells handle fuel differently, it may affect how the body uses sugar and stored energy—but it is not simply a hunger-control compound.

Research Context

Preclinical models report effects involving insulin sensitivity, adiposity and metabolic homeostasis, providing a rationale for weight-related research. Controlled human weight-loss evidence is not comparable in maturity to established incretin trials. [1]

Is MOTS-C mainly for energy or longevity?

Both ideas come from the same place. Cells that manage energy and stress well are important for how the body performs today and how tissues hold up as they age.

Research Context

Both themes arise from mitochondrial function, stress resistance and metabolic homeostasis. Longevity claims remain largely mechanistic and preclinical rather than demonstrated effects on human lifespan. [1]

What makes MOTS-C stand out?

It is a peptide made naturally inside mitochondria, linking it directly to the cell’s energy machinery. That gives it a very different story from stimulants or appetite-focused products.

Research Context

MOTS-c is a naturally occurring mitochondrial-derived signalling peptide rather than a conventional appetite agonist or stimulant. Its biology directly connects mitochondrial-encoded information with cellular adaptation to metabolic stress. [1]

Read the full Mots-C evidence guideStudy design, primary sources, limitations, and unanswered questions.Open guide
Research-use statement

This product is offered for laboratory research only. It is not for human consumption and is not represented as a medicine, treatment, supplement or substitute for an approved product.

Preparation guide

Calculate. Prepare. Store.

Confirm the selected vial and BAC-water amount, enter the target amount, then follow the preparation and storage steps.

Step 1: Calculate

The selected strength automatically opens with the easy starting rule of 1 mg = 10 units.

MOTS-C · 10 mg selected

Vial Strength
10mg

Easy rule: 1 mg = 10 units · Every 10 units = 1 mg

Calculated result
U-100 syringe20 units2 mg at the current water amount

This calculator converts the values entered. It does not choose an amount.

Step 2: Prepare

This 10 mg vial opens with 1 mL of BAC water, creating the easy starting rule of 1 mg = 10 units.

If the water amount is changed above, use the updated easy rule shown by the calculator.

Do not shake the vialSlowly add the water down the inside wall of the vial, then gently swirl until fully dissolved.

Step 3: Store

Prepared vialsRefrigerate at 2–8°C

Unprepared vialsKeep cool and dry, away from heat, moisture, and direct sunlight

Shipping & delivery

Picked And Shipped Within 24 Hours.

Every order is prepared and packed in Canada with care, accuracy, and attention to detail. In-stock orders are checked and packed within 24 hours, then shipped with Canada Post. Tracking is sent after the parcel’s first carrier scan.

Bilingual Shipped by Canada Post logo with English to the left and French to the right

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Puffin Peptides

Nice site and helpful chat bot. I’ll be back again.

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Puffin Peptides

I can’t believe it but I’ve lost 30lb. It’s been 3 months and felt compelled to write a review. I know it’s not Puffin I have to thank but their site came up in google and brought me here. Thank youuuuuu! <3

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Product documentation

Batch Details

Uploaded documents10 mg
PDF · 10 mgPP-MOTS-C-10-MG-R023.pdfPublished for MOTS-C 10 mg
View document
ProductMOTS-C
Strength10 mg
Catalogue codePP-MOTS-C-10-MG
PresentationLyophilized powder in a sealed glass vial
StorageSee vial label and lot-specific documentation
Intended useLaboratory research only · not for human consumption

Only uploaded documents published for the selected vial strength are shown here.

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